Boron tribromide → HCID 10308021, compound

HRID 1035648Notes

Reaction equation

HRID 1035648 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[C:15]([OH:19])=[CH:14][CH:13]=[CH:12]3)=[CH:5][CH:4]=1.B(Br)(Br)Br>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[C:15]([OH:19])=[CH:14][CH:13]=[CH:12]3)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 24829224HCID 24829224, compound

Product 1

HCID 10308021HCID 10308021, compoundYield 30%

Procedure

The compound is prepared by reaction of 6-(4-methoxyphenyl)-1-naphthol (57 mg, 0.23 mol, 1 eq) with boron tribromide (2.3 ml, 2.28 mmol, 10 eq) according to method G. Purification by column chromatography with dichloromethane/2% methanol as the eluent yields the desired product in a yield of 30%, 16 mg.

Workup

  1. customPurification by column chromatography with dichloromethane/2% methanol as the eluent

Sources & evidence

ORD record
ord-c10f85f3a9ee40a8bcad2618573000b3
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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