Boron tribromide → HCID 24950040, compound

HRID 1035655Notes

Reaction equation

HRID 1035655 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([O:23]C)[CH:19]=3)[CH:14]=2)[CH:12]=1)[C:6]([NH:8][CH3:9])=[O:7].B(Br)(Br)Br>>[OH:2][C:3]1[CH:4]=[C:5]([CH:10]=[C:11]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([OH:23])[CH:19]=3)[CH:14]=2)[CH:12]=1)[C:6]([NH:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 59443448HCID 59443448, compound

Product 1

HCID 24950040HCID 24950040, compound

Procedure

The compound is prepared by reaction of 3-methoxy-5-(6-methoxynaphthalene-2-yl)-N-methylbenzamide (110 mg, 0.34 mmol, 1 eq) with boron tribromide solution (5 eq) according to method G. Purification by column chromatography was not necessary. The desired product was already obtained after the processing in quantitative yield (99.6 mg).

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-a1841642b61f46fca08cdaff73e63132
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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