Aluminum(III) Chloride → HCID 24950220, compound

HRID 1035660Notes

Reaction equation

HRID 1035660 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:21][CH2:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:24])[CH:6]=[C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19]C)[CH:15]=3)[CH:10]=2)[CH:8]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[OH:2][C:3]1[CH:4]=[C:5]([CH2:21][CH2:22][C:23]([NH:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[O:24])[CH:6]=[C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:19])[CH:15]=3)[CH:10]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 59443468HCID 59443468, compound

Product 1

HCID 24950220HCID 24950220, compoundYield 23%

Procedure

The compound is prepared by reaction of 3-[3-methoxy-5-(6-methoxy-naphthalene-2-yl)phenyl]-N-phenylpropionamide (55 mg, 0.13 mmol, 1 eq) with aluminum trichloride (291.3 mg, 2.19 mmol, 12 eq) according to method F. Purification by preparative thin-layer chromatography with hexane/ethyl acetate 1/1 yielded the desired product in a yield of 23%, 17 mg.

Workup

  1. customPurification by preparative thin-layer chromatography with hexane/ethyl acetate 1/1

Sources & evidence

ORD record
ord-6f9471f2f96d4083b51016acb5b238ac
Source dataset
uspto-grants-2013_10
Patent number
US08546392B2

Reaction notes

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