反应详情

7-Methoxy-3-(3-methoxyphenyl)-1-naphthonitrile (110 mg, 0.39 mmol, 1 eq) and pyridinium hydrochloride (4.76 mmol, 12.2 eq) are boiled under reflux for 3 h. After cooling the reaction mixture, it is acidified with 1 N HCl, the resulting precipitate is filtered and dissolved in a small amount of ethyl acetate. The organic phase is washed with water, dried over magnesium sulfate, filtered and concentrated in vacuum on a rotary evaporator. The residue formed is the desired product (yield 62%, 63 mg).

1. temperatureunder reflux for 3 h
2. temperatureAfter cooling the reaction mixture, it
3. filtrationthe resulting precipitate is filtered
4. dissolutiondissolved in a small amount of ethyl acetate
5. washThe organic phase is washed with water
6. dry with materialdried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuum on a rotary evaporator
9. customThe residue formed