Hydrazine → 2-Chloro-3-hydrazinopyrazine

HRID 1035682Notes

Reaction equation

HRID 1035682 reaction equation
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.[NH2:9][NH2:10]>N1C=CC=CC=1>[Cl:1][C:2]1[C:7]([NH:9][NH2:10])=[N:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 785752,3-Dichloropyrazine

Product 1

HCID 3214302-Chloro-3-hydrazinopyrazineYield 88%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
60 °C

Procedure

2,3-Dichloropyrazine (25 g) and anhydrous hydrazine (21 ml) were dissolved in pyridine (100 mL) and heated to 60° C. After 3 h, the reaction was concentrated in vacuo to yield a residue. The residue was rinsed with water and the filtered. The resulting solid was collected by filtration and dried at 40° C. in vacuo to afford Compound 1A as a light yellow solid (20.3 g, 88%).

Workup

  1. concentrationthe reaction was concentrated in vacuo
  2. customto yield a residue
  3. washThe residue was rinsed with water
  4. filtrationThe resulting solid was collected by filtration
  5. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-f6f287973dbf4288aae12090b0ac4a4f
Source dataset
uspto-grants-2013_10
Patent number
US08546394B2

Reaction notes

Loading…