Hydrazine → 2-Chloro-3-hydrazinopyrazine

Participants

Reaction Conditions

Reaction Steps

2,3-Dichloropyrazine (25 g) and anhydrous hydrazine (21 ml) were dissolved in pyridine (100 mL) and heated to 60° C. After 3 h, the reaction was concentrated in vacuo to yield a residue. The residue was rinsed with water and the filtered. The resulting solid was collected by filtration and dried at 40° C. in vacuo to afford Compound 1A as a light yellow solid (20.3 g, 88%).

Provenance & Evidence