Acetic Anhydride → 2-(Acetylamino)-1,3-benzothiazol-6-yl thiocyanate

HRID 1035764노트

반응식

HRID 1035764 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([S:18][C:19]#[N:20])[CH:15]=[CH:14][C:12]=2[N:13]=1>N1C=CC=CC=1>[C:5]([NH:8][C:9]1[S:10][C:11]2[CH:17]=[C:16]([S:18][C:19]#[N:20])[CH:15]=[CH:14][C:12]=2[N:13]=1)(=[O:7])[CH3:6]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 816002-Amino-6-thiocyanato-1,3-benzothiazole

생성물 1

HCID 8150982-(Acetylamino)-1,3-benzothiazol-6-yl thiocyanate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5 cm3 of acetic anhydride are added dropwise to 7 cm3 of pyridine at 20° C. After 5 min, 1 g of 2-amino-6-thiocyanatobenzothiazole (commercial) is added. The yellow suspension is stirred for 4 h and then concentrated to dryness under vacuum. The residue is made into a paste in ethyl ether. The insoluble material is isolated by filtration, to give 1.1 g of 2-(acetylamino)-1,3-benzothiazol-6-yl thiocyanate in the form of a yellow solid, the characteristics of which are as follows:

후처리

  1. concentrationconcentrated to dryness under vacuum
  2. customThe insoluble material is isolated by filtration

출처 및 근거

ORD 기록
ord-104c2398a7c1451ba4c1738dbc0432bd
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546393B2

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