Cyclopropanecarbonyl chloride → 2-[(Cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate

HRID 1035773Notes

Reaction equation

HRID 1035773 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([S:11][C:12]#[N:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH:14]1([C:17](Cl)=[O:18])[CH2:16][CH2:15]1>N1C=CC=CC=1>[CH:14]1([C:17]([NH:1][C:2]2[S:3][C:4]3[CH:10]=[C:9]([S:11][C:12]#[N:13])[CH:8]=[CH:7][C:5]=3[N:6]=2)=[O:18])[CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 816002-Amino-6-thiocyanato-1,3-benzothiazole

Product 1

HCID 866478942-[(Cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocyanate was prepared in a manner similar to the method described in Example 18b, but using 2 g of commercial 2-amino-6-thiocyanatobenzothiazole and 1.21 g of cyclopropanecarboxylic acid chloride in 20 cm3 of pyridine after reaction for 5 h at 20° C. 2.65 g of 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocycanate are thus obtained in the form of a yellow powder, the characteristics of which are as follows:

Workup

  1. customafter reaction for 5 h at 20° C
  2. custom2.65 g of 2-[(cyclopropylcarbonyl)amino]-1,3-benzothiazol-6-yl thiocycanate are thus obtained in the form of a yellow powder

Sources & evidence

ORD record
ord-ed4e41f905554695908b439b14297db5
Source dataset
uspto-grants-2013_10
Patent number
US08546393B2

Reaction notes

Loading…