Methanol → HCID 178453984, compound

HRID 1035887Notes

Reaction equation

HRID 1035887 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O=[C:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1.CO.[BH4-].[Na+]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[C:17]([O:16][C:15](=[O:21])[NH:14][C@H:11]1[CH2:10][CH2:9][C@@H:8]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[CH2:13][CH2:12]1)([CH3:20])([CH3:18])[CH3:19]

Participants

6

Reactant 4

HCID 887MethanolHCID 8083MorpholineHCID 1512535tert-butyl N-(4-oxocyclohexyl)carbamateHCID 4311764Sodium borohydride

Product 1

HCID 178453984HCID 178453984, compound

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideSolvent

Procedure

To a solution of morpholine (4.08 g) and tert-butyl 4-oxocyclohexylcarbamate (10 g) stirred for 24 hours at room temperature in titanium (IV) isopropoxide (27.5 mL), methanol (10 mL) was added followed by careful addition of sodium borohydride (3.55 g). The reaction mixture was quenched with water/NaOH solution, extracted with ether, dried over magnesium sulfate, filtered, and concentrated. The product was separated from the trans isomer and purified by flash chromatography (silica gel, 50%-100% acetone in hexanes) to provide the title compound.

Workup

  1. customThe reaction mixture was quenched with water/NaOH solution
  2. extractionextracted with ether
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe product was separated from the trans isomer
  7. custompurified by flash chromatography (silica gel, 50%-100% acetone in hexanes)

Sources & evidence

ORD record
ord-d9b098241515411192dbf16173f3efa4
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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