Trifluoroacetic acid → HCID 178511581, compound

HRID 1035888Notes

Reaction equation

HRID 1035888 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[O:17]1[CH2:16][CH2:15][N:14]([C@@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453984HCID 178453984, compound

Product 1

HCID 178511581HCID 178511581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 39A (2.43 g) in dichloromethane (15 ml) was added trifluoroacetic acid (5 ml) and the reaction mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated and the crude product was used without purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was used without purification

Sources & evidence

ORD record
ord-7f73349b343b46eabddb45acad28d72d
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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