Trifluoroacetic acid → Trifluoroacetic acid

HRID 1035914Notes

Reaction equation

HRID 1035914 reaction equation
CC(OC([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12][CH2:11]1)=O)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[NH2:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([OH:16])[CH2:12][CH2:11]1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 25417625tert-Butyl [(4-hydroxycyclohexyl)methyl]carbamate

Product 2

HCID 6422Trifluoroacetic acidHCID 178511287HCID 178511287, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Tert-butyl ((1r,4r)-4-hydroxycyclohexyl)methylcarbamate (1 g) in dichloromethane (10 mL) was treated with trifluoroacetic acid (5 mL) at 0° C. for 10 minutes and at room temperature for 30 minutes. The reaction mixture was concentrated and dried in vacuo to provide the title compound as a trifluoroacetic acid salt.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-59005952259743b0837205f4d592e46b
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

Loading…