反应详情

温度

60 °C

Trans-4-Aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxy)ethane (1.07 g) and triethylamine (2.42 mL) were dissolved in anhydrous acetonitrile (20 mL). The reaction mixture was heated at 60° C. overnight. The organic solvent was removed under vacuum. The residue was purified with flash column chromatography on silica gel eluting with 7%-10% methanol in dichloromethane to give the title compound.

1. customThe organic solvent was removed under vacuum
2. customThe residue was purified with flash column chromatography on silica gel eluting with 7%-10% methanol in dichloromethane