Methyl iodide → HCID 67126619, compound

HRID 1035928Notes

Reaction equation

HRID 1035928 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:17])=[O:16])=[CH:11][C:10]=2[N+:19]([O-:21])=[O:20])[CH2:2]1.[C:22](=O)([O-])[O-].[Na+].[Na+].CI>CN(C)C=O>[CH3:22][N:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH:8][C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH2:18])(=[O:16])=[O:17])=[CH:11][C:10]=2[N+:19]([O-:21])=[O:20])[CH2:2]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 67126454HCID 67126454, compound

Product 1

HCID 67126619HCID 67126619, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of EXAMPLE 134A (158 mg) in anhydrous N,N-dimethylformamide (4 mL) was added sodium carbonate (64 mg) and methyl iodide (78 mg). After stirring overnight at room temperature, the mixture was evaporated to dryness. The crude product was then absorbed on silica gel (6 g) and purified on a silica gel column eluting with 10% methanol in dichloromethane to give the title compound.

Workup

  1. customthe mixture was evaporated to dryness
  2. customThe crude product was then absorbed on silica gel (6 g)
  3. custompurified on a silica gel column
  4. washeluting with 10% methanol in dichloromethane

Sources & evidence

ORD record
ord-09e0845d65bf4fb88f8005b9a2cd1fc0
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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