Trifluoroacetic acid → HCID 67126462, compound

HRID 1035942Notes

Reaction equation

HRID 1035942 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([O:10][C:11]3[CH:44]=[C:43]([N:45]4[CH2:50][CH2:49][N:48]([CH2:51][C:52]5[CH2:57][CH2:56][C:55]([CH3:59])([CH3:58])[CH2:54][C:53]=5[C:60]5[CH:65]=[CH:64][C:63]([Cl:66])=[CH:62][CH:61]=5)[CH2:47][CH2:46]4)[CH:42]=[CH:41][C:12]=3[C:13]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([NH:25][CH2:26][CH:27]4[CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28]4)=[C:21]([N+:38]([O-:40])=[O:39])[CH:20]=3)(=[O:18])=[O:17])=[O:14])[CH:9]=[C:4]2[CH:3]=[CH:2]1.FC(F)(F)C(O)=O>ClCCl>[NH:1]1[C:5]2=[N:6][CH:7]=[C:8]([O:10][C:11]3[CH:44]=[C:43]([N:45]4[CH2:50][CH2:49][N:48]([CH2:51][C:52]5[CH2:57][CH2:56][C:55]([CH3:59])([CH3:58])[CH2:54][C:53]=5[C:60]5[CH:61]=[CH:62][C:63]([Cl:66])=[CH:64][CH:65]=5)[CH2:47][CH2:46]4)[CH:42]=[CH:41][C:12]=3[C:13]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([NH:25][CH2:26][CH:27]4[CH2:30][NH:29][CH2:28]4)=[C:21]([N+:38]([O-:40])=[O:39])[CH:20]=3)(=[O:18])=[O:17])=[O:14])[CH:9]=[C:4]2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 87279745HCID 87279745, compound

Product 1

HCID 67126462HCID 67126462, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 161A (0.257 g) in dichloromethane (5 mL) was added trifluoroacetic acid (0.211 mL), After 30 minutes an additional 0.2 ml of trifluoroacetic acid was added. After 3 hours, the reaction was concentrated to give the title compound.

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-bd34e51f5adf4d7caa680adf29d7c07a
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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