Trifluoroacetic acid → HCID 43599637, compound

HRID 1036009Notes

Reaction equation

HRID 1036009 reaction equation
[CH:1]1([N:4]([CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:21]=[CH:20][C:19]([S:22](=[O:25])(=[O:24])[NH2:23])=[CH:18][C:17]=2[N+:26]([O-:28])=[O:27])C(=O)OC(C)(C)C)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[CH:1]1([NH:4][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[CH:21]=[CH:20][C:19]([S:22]([NH2:23])(=[O:24])=[O:25])=[CH:18][C:17]=2[N+:26]([O-:28])=[O:27])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 52224836HCID 52224836, compound

Product 1

HCID 43599637HCID 43599637, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 291C (4.14 g) in dichloromethane (10 mL) was added trifluoroacetic acid (10 mL). The mixture was stirred for 2 hours. The mixture was concentrated under vacuum and the residue was dissolved in dichloromethane (300 mL) and washed with aqueous NaHCO3, water, and brine and dried over Na2SO4. Filtration and evaporation of solvent gave the title compound.

Workup

  1. concentrationThe mixture was concentrated under vacuum
  2. dissolutionthe residue was dissolved in dichloromethane (300 mL)
  3. washwashed with aqueous NaHCO3, water, and brine
  4. dry with materialdried over Na2SO4
  5. filtrationFiltration and evaporation of solvent

Sources & evidence

ORD record
ord-0cc4a080821e46f9b205e03b4f2e9373
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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