HCID 86647915, compound → HCID 67126817, compound

HRID 1036052Notes

Reaction equation

HRID 1036052 reaction equation
[CH2:1]([C:3]1([OH:21])[CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OCC2C=CC=CC=2)[CH2:5][CH2:4]1)[CH3:2]>O1CCCC1.[Pd]>[NH2:10][CH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH2:1][CH3:2])([OH:21])[CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 86647915HCID 86647915, compound

Product 1

HCID 67126817HCID 67126817, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of EXAMPLE 358A (500 mg) and 10% Pd/C (100 mg) in tetrahydrofuran (15 mL) was stirred under H2 for 3 hours. The insoluble material was removed by filtration, and the filtrate was concentrated to provide the title compound.

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-f8e992d77ffb4d878dc092205d322a87
Source dataset
uspto-grants-2013_10
Patent number
US08546399B2

Reaction notes

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