反应详情

温度

80 °C

A solution of hydroxylamine hydrochloride (400 mg, 5.8 mmol) in 1 ml water was added to a solution of NaOAc in 1 ml water. To the resulting solution was added 1-acetyl-4-bromo-2-hydroxy-5-methylbenzene (101) (1.14 g, 5 mmol) followed by addition of 15 ml EtOH. The reaction mixture was stirred at 80° C. for 1 h. After concentrated to half of it's volume, the reaction mixture was poured in to 60 ml ice-water. Precipitate formed was filtered, washed with water and dried to give 1.19 g (yield: 97.5%, purity>95%) 5-bromo-2-((hydroxyimino)ethyl)-4-methylphenol (102) as white solid.

1. concentrationAfter concentrated to half of it's volume
2. additionthe reaction mixture was poured in to 60 ml ice-water
3. customPrecipitate formed
4. filtrationwas filtered
5. washwashed with water
6. customdried