1-Acetylpiperazine → HCID 46926731, compound

HRID 1036215Notes

Reaction equation

HRID 1036215 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=3)=[CH:14][N:13]=2)=[O:10])=[CH:4][CH:3]=1.[N:25]1([C:31](=[O:33])[CH3:32])[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>CCOC(C)=O>[C:31]([N:25]1[CH2:30][CH2:29][N:28]([C:2]2[N:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[CH:19]=4)=[CH:14][N:13]=3)=[O:10])=[CH:4][CH:3]=2)[CH2:27][CH2:26]1)(=[O:33])[CH3:32]

Participants

4

Reactant 2

HCID 837951-AcetylpiperazineHCID 58447813HCID 58447813, compound

Product 1

HCID 46926731HCID 46926731, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-(6-Chloropyridin-3-yl)-N-(5-(3-fluorophenyl)pyridin-2-yl)acetamide 140-1 (100 mg, 0.29 mmol) was heated with 1-(piperazin-1-yl)ethanone (0.8 ml) at 108° C. for 4 hours. The mixture was dissolved in EtOAc (30 ml), washed with water (40 mL), and dried over Na2SO4. After concentration by evaporation, the residue was subjected to reverse phase HPLC to afford 2-(6-(4-acetylpiperazin-1-yl)pyridin-3-yl)-N-(5-(3-fluorophenyl)pyridin-2-yl)acetamide 140 as solid.

Workup

  1. washwashed with water (40 mL)
  2. dry with materialdried over Na2SO4
  3. concentrationAfter concentration
  4. customby evaporation

Sources & evidence

ORD record
ord-a16bccc7c02a43c0b942d7716d5f2814
Source dataset
uspto-grants-2013_10
Patent number
US08546396B2

Reaction notes

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