反应详情

温度

100 °C

To the solution of 2-fluoro-5-methyl-4-(2-methylpyridin-4-yl)aniline 191-3 (1.02 g, 4.7 mmol) in CH2I2 (16 mL) was added isoamyl nitrite (6 mL) slowly at −10° C. After 20 minutes, the reaction was heated to 100° C. for 2 hours. The solvent was removed by rotary evaporation and the residue was dissolved in ethyl acetate and washed with Na2S2O5, brine and taken to dryness by rotary evaporation. The residue was purified by silica gel flash chromatography, eluted with 40% ethyl acetate in hexane to give 4-(5-fluoro-4-iodo-2-methylphenyl)-2-methylpyridine 191-4. MS m/z 328.10 (M+1).

1. customThe solvent was removed by rotary evaporation
2. dissolutionthe residue was dissolved in ethyl acetate
3. washwashed with Na2S2O5, brine
4. customtaken to dryness by rotary evaporation
5. customThe residue was purified by silica gel flash chromatography
6. washeluted with 40% ethyl acetate in hexane