Hydrochloric Acid → HCID 178482252, compound

HRID 1036309Notes

Reaction equation

HRID 1036309 reaction equation
C(O[C:6](=O)[N:7](C)[CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]=[CH:17][N:18]3C2CCCCO2)[CH2:10][CH2:9]1)(C)(C)C.Cl>C(O)C>[CH3:6][NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]=[CH:21][N:20]=[C:19]3[C:15]=2[N:16]=[CH:17][NH:18]3)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57899135HCID 57899135, compound

Product 1

HCID 178482252HCID 178482252, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of methyl-{1-[9-(tetrahydro-pyran-2-yl)-9H-purin-6-yl]-piperidin-4-yl}-carbamic acid tert-butyl ester (83 mg, 0.2 mmol), ethanol (4 ml) and 1M aqueous HCl solution (1 ml) was stirred overnight at room temperature. The solvents were then evaporated in vacuo and the crude product was purified with a flash NH2 column (2 g, 15 ml) eluting with methanol to afford the required compound (18 mg, 0.08 mmol, 39%) LC-MS (LCT) Rt 1.27 [M+H]+] 233.

Workup

  1. customThe solvents were then evaporated in vacuo
  2. customthe crude product was purified with a flash NH2 column (2 g, 15 ml)
  3. washeluting with methanol

Sources & evidence

ORD record
ord-5b5d512f0f1c4551ae15fda44c35f9a5
Source dataset
uspto-grants-2013_10
Patent number
US08546407B2

Reaction notes

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