反应详情

To 7H-pyrrolo[2,3-d]pyrimidin-4-ol (0.425 g, 3.14 mmol) was added phosphorus oxychloride (4 ml). The mixture was heated at reflux for 90 minutes and then cooled to room temperature. The solution was poured onto cracked ice, and extracted with chloroform (3×50 ml) and ethyl acetate (100 ml). The extracts were then dried and concentrated, and the residue obtained triturated with hot ethyl acetate (200 ml) to yield the title compound (0.204 g, 42%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 90 minutes
3. additionThe solution was poured
4. extractionextracted with chloroform (3×50 ml) and ethyl acetate (100 ml)
5. customThe extracts were then dried
6. concentrationconcentrated
7. customthe residue obtained
8. customtriturated with hot ethyl acetate (200 ml)