反应详情

温度

80 °C

(R)-4-(6-hydroxynaphthalen-2-yl)-4-methyloxazolidin-2-one (0.5895 g, 0.002423 mol) was suspended in acetonitrile (3.37 mL, 0.0646 mol) in a 40 mL vial equipped with a magnetic stir bar. N-Chlorosuccinimide (0.356 g, 0.00266 mol) was added and the mixture was heated at 80° C. After 2 hours, HPLC analysis showed that the reaction was complete. The mixture was cooled to room temperature and filtered. The residue was washed with acetonitrile, azeotroped with toluene then dried under vacuum and collected to give 590 mg of the title compound (62% yield).

1. customvial equipped with a magnetic stir bar
2. temperatureThe mixture was cooled to room temperature
3. filtrationfiltered
4. washThe residue was washed with acetonitrile
5. customazeotroped with toluene
6. customthen dried under vacuum
7. customcollected