反应详情

A mixture of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (673 mg, 4.41 mmol) and 7 mL of 57% hydriodic acid was stirred at room temperature for 16 hours. The solid was filtered off, suspended in 5 mL of water and brought to pH=8 with aqueous ammonia solution. The suspension was cooled down to 0° C. and the solid was filtered off, washed with cold water and dried to give the product to yield 970 mg of the product as a white powder. The product contains about 10% of the starting material.

1. filtrationThe solid was filtered off
2. temperatureThe suspension was cooled down to 0° C.
3. filtrationthe solid was filtered off
4. washwashed with cold water
5. customdried
6. customto give the product