反应详情

温度

65 °C

1,8-Diiodooctane (mmol) was added to a solution (30 mL) of isoquinoline, and the solution heated for 24 hours at 65° C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting yellow solid was isolated in an 92% yield. 1H NMR (300 MHz, DMSO-D6) δ 10.05 (1H, d, C1-H), 8.77 (1H, d, C3-H), 8.58 (1H, d, C8-H), 8.48 (1H, d, C4-H), 8.35 (1H, d, C7-H), 8.26 (1H, t, C5-H), 8.07 (1H, t, C6-H), 4.68 (2H, t, C′1-CH2), 2.00 (2H, m, C′2-CH2), 1.30 (4H, m, C′3&4-CH2).

1. filtrationThe resulting precipitate was filtered
2. washthe product washed five times with dry diethyl ether
3. customThe resulting yellow solid was isolated in an 92% yield