Hydrochloric Acid → HCID 67285382, compound

HRID 1036595Notes

Reaction equation

HRID 1036595 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14]([CH3:32])[C:15]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([NH2:31])[N:26]=3)=[C:16]([CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=3)[C:10]=2[C:9]1=[O:33])=O)(C)(C)C.[ClH:34]>O1CCOCC1>[ClH:34].[NH2:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[CH2:17][C:16]1[C:10]2[C:9](=[O:33])[NH:8][CH2:13][CH2:12][C:11]=2[N:14]([CH3:32])[C:15]=1[C:25]1[CH:30]=[CH:29][N:28]=[C:27]([NH2:31])[N:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 672845333-(3-Amino-benzyl)-2-(2-amino-pyrimidin-4-yl)-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

Product 1

HCID 67285382HCID 67285382, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A suspension of 3-(3-Amino-benzyl)-2-(2-amino-pyrimidin-4-yl)-1-methyl-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (0.030 g, 0.066 mmol) in 4 N HCl in dioxane (2 ml) was stirred at room temperature for 1 h. The solvent was removed under vacuum, affording 3-(3-Amino-benzyl)-2-(2-amino-pyrimidin-4-yl)-1-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride (0.028 g, 0.062 mmol, 100%).

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-e0ff97b9ccf84b5badd9790278bd80fb
Source dataset
uspto-grants-2013_10
Patent number
US08546413B2

Reaction notes

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