Hydrochloric Acid → 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide HCl salt

HRID 1036615Notes

Reaction equation

HRID 1036615 reaction equation
[CH2:1]([N:8]([CH:30]([CH3:32])[CH3:31])[C:9]([C:11]1[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[F:29])=[N:13][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>CCOCC>[ClH:33].[CH2:1]([N:8]([CH:30]([CH3:32])[CH3:31])[C:9]([C:11]1[C:12]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[F:29])=[N:13][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 594211924-(2-Fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide

Product 1

HCID 684577784-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide HCl saltYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide in Et2O (20 mL) was added 1N HCl in Et2O (15 mL, 15 mmol). The resulting slurry was stirred vigorously for 1 hour. The solids were filtered off, washed with Et2O (2×20 mL), and dried in vacuo (0.01 mbar) overnight to yield 4-(2-fluoro-phenyl)-2-morpholin-4-yl-pyrimidine-5-carboxylic acid benzyl-isopropyl-amide HCl salt (5.70 g, 12.10 mmol, 93%).

Workup

  1. filtrationThe solids were filtered off
  2. washwashed with Et2O (2×20 mL)
  3. customdried in vacuo (0.01 mbar) overnight

Sources & evidence

ORD record
ord-1455269405d24d35ab48a9fc560fbe1a
Source dataset
uspto-grants-2013_10
Patent number
US08546414B2

Reaction notes

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