反应详情

1-(tert-Butoxycarbonyl)azepane-4-carboxylic acid (1.0 g; 4.11 mmol) in DCM (20 ml) and treated with DIPEA (1.5 ml, 8.22 mmol) followed by trimethyloxonium tetrafluoroborate (790 mg, 5.34 mmol) in DCM (5 ml). The mixture was stirred at RT for 3 hours and concentrated in vacuo. The residue was partitioned between EtOAc and water. The organic portion was separated and the aqueous was further extracted with EtOAc. The combined organic extracts were washed with brine, dried over MgSO4 and concentrated in vacuo to afford the title compound which was used without further purification.

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between EtOAc and water
3. customThe organic portion was separated
4. extractionthe aqueous was further extracted with EtOAc
5. washThe combined organic extracts were washed with brine
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo