Bromide ion → 5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxy-2-methylpentan-3-yl)-3-methyl-3-prop-2-enylpiperidin-2-one

HRID 103674Notes

Reaction equation

HRID 103674 reaction equation
[Br-:32].[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:31])[C:5](=[O:30])[N:6]([CH:24]([C:25]([CH3:26])=[O:27])[CH2:28][CH3:29])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:33][Mg+:34].[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[CH2:1]([CH:2]=[CH2:3])[C:4]1([CH3:31])[C:5](=[O:30])[N:6]([CH:24]([C:25]([CH3:26])([OH:27])[CH3:35])[CH2:28][CH3:29])[CH:7]([c:17]2[cH:18][cH:19][c:20]([Cl:23])[cH:21][cH:22]2)[CH:8]([c:10]2[cH:11][c:12]([Cl:16])[cH:13][cH:14][cH:15]2)[CH2:9]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 1140TolueneHCID 8028TetrahydrofuranHCID 178438866HCID 178438866, compoundHCID 178477777HCID 178477777, compound

Product 1

HCID 768346325-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxy-2-methylpentan-3-yl)-3-methyl-3-prop-2-enylpiperidin-2-one

Sources & evidence

ORD record
ord-fd5ccae04be34de0b3ef295a74a57fee
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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