Ethyl 4,5-dibromothiophene-2-carboxylate → Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate

HRID 1036987Notes

Reaction equation

HRID 1036987 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:5][C:6]=1[C:7]1[CH:12]=[C:11](F)[CH:10]=[C:9]([Cl:14])[CH:8]=1.BrC1C=C(C(OCC)=O)SC=1Br>>[Br:1][C:2]1[CH:3]=[C:4]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:14])[CH:8]=1

Participants

3

Reactant 2

HCID 15073982Ethyl 4,5-dibromothiophene-2-carboxylateHCID 58066756Ethyl 4-bromo-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate

Product 1

HCID 58066739Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 9A starting with the compound from Example 8A. 125 mg (57% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-7f1c8a2e60684095a4b6c4cb14060a1f
Source dataset
uspto-grants-2013_10
Patent number
US08546438B2

Reaction notes

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