Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylate → 5-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid

HRID 1036995Notes

Reaction equation

HRID 1036995 reaction equation
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[S:37][C:36]([C:38]([O:40]CC)=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[CH:47][C:46]([F:49])=[C:45]([C:50]#[N:51])[CH:44]=2)[CH:29]=[C:30]([F:32])[CH:31]=1>>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[S:37][C:36]([C:38]([OH:40])=[O:39])=[CH:35][C:34]=2[C:43]2[CH:48]=[CH:47][C:46]([F:49])=[C:45]([C:50]#[N:51])[CH:44]=2)[CH:29]=[C:30]([F:32])[CH:31]=1

Participants

3

Reactant 2

HCID 58066742Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Product 1

HCID 580667555-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 18A. 82.3 mg (97% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-eb38378555a94d9abee1532849d9eca1
Source dataset
uspto-grants-2013_10
Patent number
US08546438B2

Reaction notes

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