HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylate → 5-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylate | HCID 58066742 | — |
| Reactant | 5-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid | HCID 58066757 | — |
| Product | 5-(3-Chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylic acid | HCID 58066755 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 18A. 82.3 mg (97% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546438B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-eb38378555a94d9abee1532849d9eca1 |
| Source note | uspto-grants-2013_10 |