Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylate → 4-Bromo-5-(3-chlorophenyl)thiophene-2-carboxylic acid

HRID 1036996Notes

Reaction equation

HRID 1036996 reaction equation
ClC1C=C(C2SC(C(O)=O)=CC=2C2C=CC=C(C#N)C=2)C=C(F)C=1.[Br:25][C:26]1[CH:27]=[C:28]([C:38]([O:40]CC)=[O:39])[S:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1>>[Br:25][C:26]1[CH:27]=[C:28]([C:38]([OH:40])=[O:39])[S:29][C:30]=1[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[CH:32]=1

Participants

3

Reactant 2

HCID 58066739Ethyl 4-bromo-5-(3-chlorophenyl)thiophene-2-carboxylateHCID 580667575-(3-Chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Product 1

HCID 580667484-Bromo-5-(3-chlorophenyl)thiophene-2-carboxylic acid

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 19A starting with the compound from Example 10A. 1.11 g (100% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-4bc8664ec83249ce892fef9ccf5745e9
Source dataset
uspto-grants-2013_10
Patent number
US08546438B2

Reaction notes

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