Ethyl 4,5-dibromothiophene-2-carboxylate → 3-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile

HRID 1037004Notes

Reaction equation

HRID 1037004 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])[S:11][C:10]=2[C:22]2[CH:23]=[C:24]([C:29]#[N:30])[CH:25]=[C:26]([F:28])[CH:27]=2)[CH:5]=[CH:6][C:7]=1F.BrC1C=C(C(OCC)=O)SC=1Br>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:13]=[C:12]([C:14]([N:16]3[CH2:20][C:19](=[O:21])[NH:18][CH2:17]3)=[O:15])[S:11][C:10]=2[C:22]2[CH:23]=[C:24]([C:29]#[N:30])[CH:25]=[C:26]([F:28])[CH:27]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 15073982Ethyl 4,5-dibromothiophene-2-carboxylateHCID 468340763-{3-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile

Product 1

HCID 468340773-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile

Procedure

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 10 starting with the compound from Example 8A. 8.2 mg (1% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-96f4cc26e8cd4a11b10b3f88ce1372d7
Source dataset
uspto-grants-2013_10
Patent number
US08546438B2

Reaction notes

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