HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4,5-dibromothiophene-2-carboxylate → 3-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4,5-dibromothiophene-2-carboxylate | HCID 15073982 | — |
| Reactant | 3-{3-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile | HCID 46834076 | — |
| Product | 3-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile | HCID 46834077 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 10 starting with the compound from Example 8A. 8.2 mg (1% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546438B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-96f4cc26e8cd4a11b10b3f88ce1372d7 |
| Source note | uspto-grants-2013_10 |