2-Fluoro-6-methoxybenzaldehyde → 1-(2-Fluoro-6-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

HRID 1037159Notes

Reaction equation

HRID 1037159 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.[F:20]C1C=CC=C(OC)C=1C=O>>[F:20][C:7]1[CH:2]=[CH:3][CH:4]=[C:5]([O:18][CH3:19])[C:6]=1[CH:8]([OH:17])[C:9]#[C:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 27373572-Fluoro-6-methoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 670676291-(2-Fluoro-6-methoxy-phenyl)-3-phenyl-prop-2-yn-1-olYield 77%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-fluoro-6-methoxy-benzaldehyde (947 mg, 6.14 mmol) was reacted to give the title compound (1.21 g, 77%). 1H NMR (400 MHz, DMSO-d6): δ 7.41-7.30 (m, 6H), 6.91-6.79 (m, 2H), 5.97-5.94 (m, 1H), 5.90-5.87 (d, 1H), 3.86 (s, 3H).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-4b36a16ec3a24b37a19c6178548755ed
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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