HCID 15152169, compound → HCID 67067797, compound

HRID 1037166Notes

Reaction equation

HRID 1037166 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24](F)[CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].IC1C(=O)C2C(=CC=C(OC)C=2)[O:40][C:39]=1C1C=CC=CC=1>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:27](=[O:28])[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:40][CH3:39])[CH:25]=4)[O:20][C:19]=3[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 15152169HCID 15152169, compoundHCID 67067635{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Product 1

HCID 67067797HCID 67067797, compoundYield 44%

Procedure

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 3-iodo-6-methoxy-2-phenyl-chromen-4-one (76 mg, 0.20 mmol) was reacted to give the title compound (42 mg, 44%). 1H NMR (400 MHz, CDCl3): δ 7.68-7.64 (d, 1H), 7.51-7.16 (m, 11H), 5.05 (s, 1H), 3.92 (s, 3H), 2.61-2.45 (m, 4H), 2.16-1.75 (m, 2H), 1.52-1.00 (m, 9H).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-d6aca42f0f98494ca0d4b63de4f19595
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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