4-Bromo-2-methoxybenzaldehyde → HCID 67067707, compound

HRID 1037185Notes

Reaction equation

HRID 1037185 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.COC1C=C([Br:30])C=CC=1C=O>>[Br:30][C:3]1[CH:2]=[CH:7][C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:5]([O:18][CH3:19])[CH:4]=1

Participants

3

Reactant 2

HCID 110530414-Bromo-2-methoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 67067707HCID 67067707, compoundYield 96%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-methoxy-4-bromobenzaldehyde was reacted to give the title compound as a pale yellow oil (1.43 g, 96%). LCMS (Method B): RT=4.53 min, [M+H]+=299/301.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-d3e28966f685416cadb22b71d0614cd5
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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