HCID 11718442, compound → HCID 67067743, compound

HRID 1037191Notes

Reaction equation

HRID 1037191 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15](C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].I[C:38]1[C:47](=[O:48])[C:46]2[C:41](=[CH:42][C:43]([O:51][CH3:52])=[C:44]([O:49][CH3:50])[CH:45]=2)[O:40][C:39]=1[C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:38]3[C:47](=[O:48])[C:46]4[C:41](=[CH:42][C:43]([O:51][CH3:52])=[C:44]([O:49][CH3:50])[CH:45]=4)[O:40][C:39]=3[C:53]3[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=3)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 11718442HCID 11718442, compoundHCID 67067635{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Product 1

HCID 67067743HCID 67067743, compoundYield 86%

Procedure

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 3-iodo-6,7-dimethoxy-2-phenyl-chromen-4-one was reacted to give the title compound as a white solid (68 mg, 86%). LCMS (Method B): RT=4.81 min, [M+H]+=528.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-05cd93da6dc2490798a9b3fef479033b
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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