4,5-Difluoro-2-methoxybenzaldehyde → 3-Phenyl-1-(2-methoxy-4,5-difluoro-phenyl)-prop-2-yn-1-ol

HRID 1037208Notes

Reaction equation

HRID 1037208 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.COC1C=C([F:30])C(F)=CC=1C=O>>[C:11]1([C:10]#[C:9][CH:8]([C:6]2[CH:7]=[C:2]([F:1])[C:3]([F:30])=[CH:4][C:5]=2[O:18][CH3:19])[OH:17])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 154345524,5-Difluoro-2-methoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 670676443-Phenyl-1-(2-methoxy-4,5-difluoro-phenyl)-prop-2-yn-1-olYield 97%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-methoxy-4,5-difluorobenzaldehyde was reacted to give the title compound as a colourless oil (531 mg, 97%). LCMS (Method B): RT=3.90 min, [M−H2O+H]+=257.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-6ee4f3b6a50f4a4694b497026caa2f7b
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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