HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Difluoro-2-methoxybenzaldehyde → 3-Phenyl-1-(2-methoxy-4,5-difluoro-phenyl)-prop-2-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Difluoro-2-methoxybenzaldehyde | HCID 15434552 | — |
| Reactant | 1-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol | HCID 67067672 | — |
| Product | 3-Phenyl-1-(2-methoxy-4,5-difluoro-phenyl)-prop-2-yn-1-ol | HCID 67067644 | 97% |
Reaction Steps
Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-methoxy-4,5-difluorobenzaldehyde was reacted to give the title compound as a colourless oil (531 mg, 97%). LCMS (Method B): RT=3.90 min, [M−H2O+H]+=257.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546376B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-6ee4f3b6a50f4a4694b497026caa2f7b |
| Source note | uspto-grants-2013_10 |