2-Methoxy-5-(trifluoromethoxy)benzaldehyde → 1-(2-Methoxy-5-trifluoromethoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

HRID 1037214Notes

Reaction equation

HRID 1037214 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([O:18][CH3:19])=[C:6]([CH:8]([OH:17])[C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:7]=1.COC1C=CC([O:30][C:31]([F:34])([F:33])[F:32])=CC=1C=O>>[CH3:19][O:18][C:5]1[CH:4]=[CH:3][C:2]([O:30][C:31]([F:34])([F:33])[F:32])=[CH:7][C:6]=1[CH:8]([OH:17])[C:9]#[C:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 27833642-Methoxy-5-(trifluoromethoxy)benzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 670676931-(2-Methoxy-5-trifluoromethoxy-phenyl)-3-phenyl-prop-2-yn-1-olYield 99%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2-methoxy-5-trifluoromethoxy-benzaldehyde was reacted to give the title compound as a pale yellow oil (642 mg, 99%). LCMS (Method B): RT=4.55 min, [M−H2O+H]+=305.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b4a2a4d7b51b45069a1324e025fb7808
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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