5-Bromo-2,4-dimethoxybenzaldehyde → HCID 67067675, compound

HRID 1037220Notes

Reaction equation

HRID 1037220 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5](OC)=[C:6]([CH:8](O)[C:9]#CC2C=CC=CC=2)[CH:7]=1.[CH3:20][O:21][C:22]1[CH:29]=[C:28]([O:30][CH3:31])[C:27]([Br:32])=[CH:26][C:23]=1[CH:24]=[O:25]>>[Br:32][C:27]1[C:28]([O:30][CH3:31])=[CH:29][C:22]([O:21][CH3:20])=[C:23]([CH:24]([OH:25])[C:9]#[C:8][C:6]2[CH:7]=[CH:2][CH:3]=[CH:4][CH:5]=2)[CH:26]=1

Participants

3

Reactant 2

HCID 6683465-Bromo-2,4-dimethoxybenzaldehydeHCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 67067675HCID 67067675, compoundYield 100%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2,4-dimethoxy-5-bromobenzaldehyde was reacted to give the title compound as a yellow foam (1.43 g, 100%). LCMS (Method B): RT=4.99 min, [M+Na]+=369/371.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b45ac040c0624aadbeb2f7d4bda1421a
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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