3-Iodo-7-methoxy-2-phenyl-pyrano[2,3-b]pyridin-4-one → 3-Iodo-2-phenyl-8H-pyrano[2,3-b]pyridine-4,7-dione

Participants

Reaction Conditions

Reaction Steps

A suspension of 3-iodo-7-methoxy-2-phenyl-pyrano[2,3-b]pyridin-4-one (0.25 g, 0.66 mmol) in 33% hydrogen bromide solution in AcOH (3.5 mL) was heated in a microwave oven at 60° C. for 50 min. The resultant solution was evaporated to dryness. Toluene was added to the residual solid and evaporated. The orange solid was used without further purification. LCMS (Method B): RT=3.85 min, [M+H]+=366.

Provenance & Evidence