反应详情

温度

60 °C

A suspension of 3-iodo-7-methoxy-2-phenyl-pyrano[2,3-b]pyridin-4-one (0.25 g, 0.66 mmol) in 33% hydrogen bromide solution in AcOH (3.5 mL) was heated in a microwave oven at 60° C. for 50 min. The resultant solution was evaporated to dryness. Toluene was added to the residual solid and evaporated. The orange solid was used without further purification. LCMS (Method B): RT=3.85 min, [M+H]+=366.

1. customThe resultant solution was evaporated to dryness
2. additionToluene was added to the residual solid
3. customevaporated
4. customThe orange solid was used without further purification