HRID1037248

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4ccc(F)cc4c3=O)cc2)CCC1

HCID67067635

未命名化合物

HCID86671024

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NC1(c2ccc(-c3c(-c4ccccc4)oc4nc(Cl)ccc4c3=O)cc2)CCC1

HCID86671025

未命名化合物

收率 64%

PROCEDURE

实验过程

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-chloro-3-iodo-2-phenyl-pyrano[2,3-b]pyridin-4-one was reacted to give the title compound (8.4 mg, 64%) as a colourless gum. LCMS (Method B): RT=4.42 min, [M+Na]+=525/527.

WORKUP

后处理

customwas reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1dfcaed8ac9b406eb72941e59857e441
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08546376B2
来源说明: uspto-grants-2013_10

反应 SMILES

[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15](C3C(=O)C4C(=CC=C(F)C=4)OC=3C3C=CC=CC=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[Cl:37][C:38]1[N:43]=[C:42]2[O:44][C:45]([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[C:46](I)[C:47](=[O:48])[C:41]2=[CH:40][CH:39]=1>>[C:1]([O:5][C:6](=[O:36])[NH:7][C:8]1([C:12]2[CH:13]=[CH:14][C:15]([C:46]3[C:47](=[O:48])[C:41]4[C:42]([O:44][C:45]=3[C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)=[N:43][C:38]([Cl:37])=[CH:39][CH:40]=4)=[CH:16][CH:17]=2)[CH2:9][CH2:10][CH2:11]1)([CH3:4])([CH3:2])[CH3:3]