{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester → {1-[4-(7-Chloro-4-oxo-2-phenyl-4H-pyrano[2,3-b]pyridin-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	{1-[4-(6-Fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 67067635	—
Reactant	7-Chloro-3-iodo-2-phenyl-pyrano[2,3-b]pyridin-4-one	HCID 86671024	—
Product	{1-[4-(7-Chloro-4-oxo-2-phenyl-4H-pyrano[2,3-b]pyridin-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester	HCID 86671025	64%

Reaction Steps

Following the procedure used to prepare {1-[4-(6-fluoro-4-oxo-2-phenyl-4H-chromen-3-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester, 7-chloro-3-iodo-2-phenyl-pyrano[2,3-b]pyridin-4-one was reacted to give the title compound (8.4 mg, 64%) as a colourless gum. LCMS (Method B): RT=4.42 min, [M+Na]+=525/527.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08546376B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-1dfcaed8ac9b406eb72941e59857e441
Source note	uspto-grants-2013_10