2-Chloro-3-methoxypyridine-4-carbaldehyde → 1-(2-Chloro-3-methoxy-pyridin-4-yl)-3-phenyl-prop-2-yn-1-ol

HRID 1037258Notes

Reaction equation

HRID 1037258 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][CH:6]=C(OC)N=1.[Cl:21][C:22]1C(OC)=C(C=O)C=C[N:23]=1>>[Cl:21][C:22]1[C:3]([O:2][CH3:1])=[C:8]([CH:9]([OH:18])[C:10]#[C:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:7]=[CH:6][N:23]=1

Participants

3

Reactant 2

HCID 597277402-Chloro-3-methoxypyridine-4-carbaldehydeHCID 670678161-(2,6-Dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol

Product 1

HCID 866710301-(2-Chloro-3-methoxy-pyridin-4-yl)-3-phenyl-prop-2-yn-1-olYield 100%

Procedure

Following the procedure used to prepare 1-(2,6-dimethoxy-pyridin-3-yl)-3-phenyl-prop-2-yn-1-ol, 2-chloro-3-methoxy-pyridine-4-carbaldehyde was reacted to give the title compound (1.60 g, 100%) as a colourless solid, LCMS (Method A): RT=4.14 min, [M+H]+=274/276.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c11d342059f74501a2ad132532ca7d68
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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