HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-FLUORO-3-IODO-2-PHENYLCHROMEN-4-ONE → 7-[4-(1-Amino-cyclobutyl)-phenyl]-8-phenyl-1H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-FLUORO-3-IODO-2-PHENYLCHROMEN-4-ONE | HCID 11523469 | — |
| Reactant | HCID 67067758 | HCID 67067758 | — |
| Reactant | 7-Iodo-6-oxo-8-phenyl-6H-9-oxa-1,2-diaza-cyclopenta[a]naphthalene-1-sulfonic acid dimethylamide | HCID 67067832 | — |
| Product | 7-[4-(1-Amino-cyclobutyl)-phenyl]-8-phenyl-1H-9-oxa-1,2-diaza-cyclopenta[a]naphthalen-6-one | HCID 51029949 | 82% |
Reaction Steps
7-Iodo-6-oxo-8-phenyl-6H-9-oxa-1,2-diaza-cyclopenta[a]naphthalene-1-sulfonic acid dimethylamide Following the procedure used to prepare 6-fluoro-3-iodo-2-phenyl-chromen-4-one, 7-methoxy-6-(3-phenyl-propynoyl)-indazole-1-sulfonic acid dimethylamide was reacted to give the title compound as a tan solid (173 mg, 82%). LCMS (Method B): RT=4.42 min, [M+H]+=496.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08546376B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-7cbb55b3d137480380718870697473c0 |
| Source note | uspto-grants-2013_10 |