6-FLUORO-3-IODO-2-PHENYLCHROMEN-4-ONE → HCID 86671039, compound

HRID 1037313Notes

Reaction equation

HRID 1037313 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10]C=1)[O:8][C:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[C:6]([I:18])[C:5]2=[O:19].COC1C2[N:24]([C:38](=[O:49])[N:39]([CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])[N:40]=2)C=CC=1C(=O)C#CC1C=CC=CC=1>>[I:18][C:6]1[C:5](=[O:19])[C:4]2[CH:3]=[CH:2][N:24]3[C:38](=[O:49])[N:39]([CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])[N:40]=[C:10]3[C:9]=2[O:8][C:7]=1[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 115234696-FLUORO-3-IODO-2-PHENYLCHROMEN-4-ONEHCID 67067859HCID 67067859, compound

Product 1

HCID 86671039HCID 86671039, compoundYield 81%

Procedure

Following the procedure used to prepare 6-fluoro-3-iodo-2-phenyl-chromen-4-one, 8-methoxy-7-(3-phenyl-propynoyl)-2-(2-trimethylsilanyl-ethoxymethyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one was reacted to give the title compound as a cream solid (958 mg, 81%). LCMS (Method A): RT=4.80 min, [M+H]+=536.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-31e0a207f4d04d079545da0069ddeaab
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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