1-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol → HCID 67067891, compound

HRID 1037359Notes

Reaction equation

HRID 1037359 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5](OC)=[C:6]([CH:8](O)[C:9]#CC2C=CC=CC=2)[CH:7]=1.[CH3:20][O:21][C:22]1[C:29]([O:30][CH3:31])=[C:28]([N+:32]([O-:34])=[O:33])[CH:27]=[CH:26][C:23]=1[CH:24]=[O:25]>>[CH3:20][O:21][C:22]1[C:29]([O:30][CH3:31])=[C:28]([N+:32]([O-:34])=[O:33])[CH:27]=[CH:26][C:23]=1[CH:24]([OH:25])[C:9]#[C:8][C:6]1[CH:7]=[CH:2][CH:3]=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 670676721-(5-Fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-olHCID 86671053HCID 86671053, compound

Product 1

HCID 67067891HCID 67067891, compoundYield 91%

Procedure

Following the procedure used to prepare 1-(5-fluoro-2-methoxy-phenyl)-3-phenyl-prop-2-yn-1-ol, 2,3-dimethoxy-4-nitro-benzaldehyde was reacted to give the title compound as a colourless oil (1.42 g, 91%). LCMS (Method G): RT=3.66 min, [M−OH+H]+=297.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-8329634fc224446184cbe033fd610eec
Source dataset
uspto-grants-2013_10
Patent number
US08546376B2

Reaction notes

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